Metrics details. The aberrant expression of miRNAs is associated with many diseases and they have both therapeutic and biomarker potential. However, our understanding of their usefulness is dependent on the tools we have to study them. Previous studies have identified the need to optimise and standardise RNA extraction methods in order to avoid biased results.
RNA structures of coronavirus reveal potential drug targets
No, Sloan Kettering Did Not Say mRNA Vaccines 'Promote Cancer'
University of Maryland scientists have developed a method to determine the structures of large RNA molecules at high resolution. The method overcomes a challenge that has limited 3D analysis and imaging of RNA to only small molecules and pieces of RNA for the past 50 years. The new method, which expands the scope of nuclear magnetic resonance NMR spectroscopy, will enable researchers to understand the shape and structure of RNA molecules and learn how they interact with other molecules. The insights provided by this technology could lead to targeted RNA therapeutic treatments for disease.
Fact check: A 2012 study did not use mRNA vaccines or result in animals dying from disease
Metrics details. The database provides a comprehensive repository of computationally predicted ribosome-associated circRNAs; a manually curated collection of experimentally verified translated circRNAs; an evaluation of cross-species conservation of translatable circRNAs; a systematic de novo annotation of putative circRNA-encoded peptides, including sequence, structure, and function; and a genome browser to visualize the context-specific occupant footprints of circRNAs. Recent advances in computational analysis and high-throughput RNA sequencing RNA-seq have unveiled a detailed view of circRNA biogenesis, regulatory mechanisms, and cellular functions [ 1 ]. These transcriptome data-oriented databases provide essential information about circRNAs, facilitating the current understanding of circRNAs related to their biological importance and clinical relevance.
The discovery of DNA began in when the British bacteriologist Frederick Griffith was performing an experiment with mice based on pneumococcus, a bacterium that causes pneumonia in humans. This bacterium has a capsule made of polysaccharides that has a shiny and smooth appearance, called s-strain. There are mutants of s-strain that do not produce this capsule and form a rough-looking colony called r-strain. Griffith discovered that this mutant did not kill the mice, but if pneumococcus R was. Although RAPD is a simple and inexpensive technique its major limitation is the inability to differentiate.