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Osmotic drug delivery system research paper

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Abstract Conventional drug delivery system provides an immediate release of drug which does not control the release of the drug and does not maintain effective concentration at target site for a longer period of time. Hence to avoid the shortcomings there is development of various controlled drug delivery systems. Among these osmotic drug delivery system ODDS utilizes the principle of osmotic pressure and delivers drug dose in an optimized manner to maintain drug concentration within the therapeutic window and minimizes toxic effects. ODDS releases drug at a controlled rate that is independent of the pH and thermodynamics of dissolution medium. The release of drug from ODDS follows zero order kinetics. The release of drug from osmotic system depends upon various formulation factors such as solubility, osmotic pressure of the core components, size of the delivery orifice and nature of the rate controlling membrane.
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Drug Delivery Technology to the CNS in the Treatment of Brain Tumors: The Sherbrooke Experience

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Osmotic drug delivery systems: basics and design approaches

Development of asymmetric membrane capsules of metformin hydrochloride for oral osmotic controlled drug delivery. Departments of Pharmaceutics, and Pharmacognosy, M. Asymmetric membrane capsules are one of the novel osmotic delivery devices which offer the delivery of a wide range of drugs in a controlled manner. In the present work, we developed a semi-automatic process by fabricating a hydraulic assisted mechanical robotic arm for the manufacturing of asymmetric membrane capsules and the process was validated in comparison with the manual procedure of manufacturing. The comparative examination of physical parameters in manual and semi-automatic process confirmed the consistency, reproducibility and efficiency of the semi-automatic process over manual procedure.
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Drug delivery

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